The section for virology strives to increase the current knowledge of new and existing viral pathogens, to bridge both animal and human health and life science and engineering. They collaborate with leading partners, both nationally and internationally, in order to contribute new scientific discoveries, develop innovative tools and services and novel types of interventions.
Responsibilities and tasks
The picornavirus family includes many important animal and human pathogens including foot-and-mouth disease virus (FMDV), poliovirus and human rhinoviruses (causing the “common cold”). Picornavirus particles comprise 60 copies of 4 different proteins (VP1-VP4)) surrounding a single copy of the RNA genome. The correct assembly of these complex structures is critical for the infectious cycle of the virus. Understanding the processes of virus assembly and disassembly can provide opportunities for interfering in the virus life cycle and hence blocking infection. This project will seek to identify cellular proteins contributing to the assembly and disassembly of virus particles during the virus life cycle and then to explore their role. The work will involve the use of genetically modified viruses, containing epitope tags, to enable the specific capture of viral proteins (and associated cellular proteins) during the steps of virus assembly and breakdown.
Qualifications
Candidates should have a master’s degree in biological sciences or a similar degree with an academic level equivalent to the master’s degree in this area.
The workplace will be at DTU Vet, Lindholm, Denmark.
Application deadline: 10 August 2015
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